* New York City: As the main gateway for immigrants entering the United States, New York City became home to diverse immigrant communities from various countries, including Ireland, Italy, Germany, Poland, and Eastern Europe.
* Boston: With a strong manufacturing sector and its proximity to Ellis Island, Boston attracted many immigrants from Ireland, Italy, and Eastern Europe.
* Philadelphia: Known as the "Workshop of the World" during the Industrial Revolution, Philadelphia attracted immigrants from Germany, Ireland, and Italy, who found employment in factories and industries.
* Chicago: A major transportation hub and center for meatpacking and steel industries, Chicago attracted immigrants from Poland, Italy, Germany, and Eastern Europe, who contributed to the city's economic growth.
* San Francisco: The West Coast's primary entry point for immigrants, San Francisco welcomed Chinese, Japanese, Irish, and Italian immigrants, shaping its diverse cultural landscape.
Other urban centers, such as Baltimore, Detroit, Pittsburgh, and Los Angeles, also attracted significant immigrant populations. Immigrants often settled in close-knit ethnic enclaves or "Little" communities, where cultural traditions, languages, and institutions from their home countries were preserved.