1. Roanoke Colony: Established by English settlers on Roanoke Island (present-day North Carolina) in 1585, the Roanoke Colony mysteriously vanished without a trace, leading to the famous "Lost Colony" mystery.
2. Popham Colony: Founded by English settlers in 1607 on the Kennebec River in present-day Maine, the Popham Colony was abandoned within a year due to harsh conditions and conflicts with Native Americans.
3. Jamestown Colony: Established in 1607 by English settlers on the James River in present-day Virginia, while Jamestown is often regarded as the first permanent English settlement in North America, it faced numerous challenges and near collapses in its early years.
4. Charles Fort: This French colony was founded in 1562 in present-day South Carolina. It was abandoned after only two years due to disease and conflicts with Native Americans.