2. The issue of tariffs. The Southern states were generally opposed to tariffs, which they saw as a tax on their exports, while the Northern states were generally in favor of tariffs, which they saw as a way to protect their industries. This issue was a major factor in the Nullification Crisis of 1832-1833.
3. The issue of states' rights. The Southern states were generally more in favor of states' rights, while the Northern states were generally more in favor of a strong federal government. This issue was a major factor in the Kentucky and Virginia Resolutions of 1798-1799, and it was also a key factor in the outbreak of the Civil War.