Gandhi was born in Mumbai, India. He completed his bachelor's degree in commerce from Sydenham College before turning to filmmaking. He started his career directing short films and music videos.
In 2009, Gandhi's debut feature film Kaminey was released. The film earned critical acclaim for its screenplay, performances, and direction. It won numerous awards, including the Screen Award for Best Screenplay and the Filmfare Critics Award for Best Film.
In 2015, Gandhi released his second feature film, Talvar. The film is based on the real-life Aarushi Talwar murder case. Talvar also received critical acclaim for its screenplay, performances, and direction. It won numerous awards, including the National Film Award for Best Screenplay and the Filmfare Critics Award for Best Film.
In 2020, Gandhi released his third feature film, Raat Akeli Hai. The film is set in North India and is about a police officer investigating the murder of a politician. Raat Akeli Hai received positive reviews from critics and was praised for its screenplay, performances, and direction.