- Ra: Osiris was often considered to be the son of Ra, the sun god, and consequently regarded as a manifestation of the sun's power and authority.
- Geb: In some versions of Egyptian mythology, Osiris was seen as the son of Geb, the earth god.
- Nephthys: Nephthys, the goddess of mourning, lamentation, and childbirth, was often depicted as Osiris' sister and the wife of his brother, Seth.
- Set(h): Set, or Seth, was Osiris' brother and played a significant role in Egyptian mythology. He was frequently portrayed as the god of chaos, violence, and storms, and was responsible for the murder of Osiris.
- Thoth: Thoth, the god of wisdom, writing, and magic, played an important role in the story of Osiris' resurrection and was integral to the restoration of order and harmony in the Egyptian pantheon.
The relationships between these deities were often complex and varied across different periods of ancient Egyptian history and in various religious contexts.