Here are some of the key events that took place during the 16th century exploration:
* 1492: Christopher Columbus, an Italian explorer in the service of Spain, reached the Americas, sparking the European colonization of the New World.
* 1497: Vasco da Gama, a Portuguese explorer, reached India, establishing a direct sea route between Europe and Asia.
* 1519-1522: Ferdinand Magellan, a Portuguese explorer in the service of Spain, led the first expedition to circumnavigate the world.
* 1521: Hernán Cortés, a Spanish conquistador, defeated the Aztec Empire and established Spanish rule in Mexico.
* 1532: Francisco Pizarro, a Spanish conquistador, defeated the Inca Empire and established Spanish rule in Peru.
* 1542: Juan Rodríguez Cabrillo, a Portuguese explorer in the service of Spain, explored the west coast of North America, from present-day California to Oregon.
* 1565: Pedro Menéndez de Avilés, a Spanish explorer, founded St. Augustine, Florida, the oldest continuously occupied European settlement in the United States.
* 1577-1580: Sir Francis Drake, an English explorer, circumnavigated the world.
These are just a few of the many important events that took place during the 16th century exploration. This period of exploration had a profound impact on the world, shaping the course of history and laying the foundation for the modern world.