The killing of many Native Americans by Europeans was a result of various factors, including conflicts over land and resources, cultural differences, and the spread of diseases. Europeans sought to expand their territories and exploit the resources of the Americas, leading to clashes with Native American tribes who were defending their ancestral lands and way of life. Additionally, European colonists brought with them infectious diseases such as smallpox, measles, and influenza, which decimated Native American populations as they had no natural immunity to these diseases. Other factors contributing to the deaths of Native Americans included forced labor, displacement, and cultural disruption caused by European colonization.