There is no definitive answer to this question as it depends on a variety of factors, such as climate change, natural disasters, and human activity. However, some regions of the world are more vulnerable to these threats than others. For example, low-lying coastal areas are at risk of flooding from rising sea levels, while areas that are prone to earthquakes and volcanic eruptions are at risk of destruction from these natural disasters. Additionally, regions that are heavily polluted or that have high levels of deforestation are at risk of environmental damage that could make them uninhabitable. Ultimately, it is difficult to predict which region of the world will end first, but it is important to be aware of the threats that these regions face and to take steps to mitigate them.