- Eric Roberts as Al Capone
- Kevin Gage as Frank Nitti
- Anthony LaPaglia as Ralph Capone
- Dennis Farina as Salvatore "Solly" DeLaurentis
- Billy Drago as Frank "Tight Lips" Fratello
- Michael Nouri as Mike Coscia
- Joe Mantegna as Genovese crime family hitman
- Ron Dean as Frank Cline
- John Harkins as Walter Dietrich
- John Cassini as Frank Caruso
- Paul Ben-Victor as Jack McGurn