1. Louisa Maria Teresa Stuart: Born on June 28, 1692, Louisa Maria Teresa was Charles Edward's elder sister. She became a nun and took the name Sister Teresa Angela.
2. Anne Louise Benedicte Stuart: Born on June 18, 1695, Anne Louise Benedicte was another elder sister of Charles Edward. She married Louis Alexandre, Prince of Lorraine, and was known as the Duchess of Lorraine.
3. Henry Benedict Thomas Edward Maria Clement Francis Xavier Stuart: Born on March 6, 1725, Henry Benedict was Charles Edward's younger brother. He became a Catholic cardinal and is often referred to as "Cardinal York."
4. Maria Clementina Sobieska: Born on July 18, 1702, Maria Clementina was Charles Edward's mother. She was the daughter of James Louis Sobieski, the son of King John III Sobieski of Poland.