* Mathematician and logician
* Developed Boolean algebra, which is used in computer science and engineering
John Philip Holland
* Inventor and engineer
* Designed and built the first successful submarine, the Fenian Ram
Ernest Walton
* Physicist
* Co-winner of the Nobel Prize in Physics in 1951 for his work on the splitting of the atom
William Parsons, 3rd Earl of Rosse
* Astronomer and engineer
* Built the world's largest telescope, the Leviathan of Parsonstown
Harry Ferguson
* Engineer and inventor
* Developed the Ferguson tractor, which was the first tractor with a three-point hitch
Charles Parsons
* Engineer and inventor
* Invented the steam turbine, which is used in power plants and ships
James Joyce
* Writer and poet
* Considered one of the most influential writers of the 20th century
Oscar Wilde
* Writer and playwright
* Known for his wit and flamboyant personality
George Bernard Shaw
* Playwright and critic
* Winner of the Nobel Prize in Literature in 1925