The relationship between settlers and Native Americans was complex and varied over time. There were periods of conflict and violence, as well as periods of peace and cooperation. Often conflict arose over land and resources, as settlers moved into Native American territories. In some cases, settlers took land by force, while in other cases, Native Americans sold land and signed treaties with the settlers. Some Native American groups resisted European colonization, while others accommodated and sought to negotiate favorable terms. The interaction between settlers and Native Americans was shaped by various factors, including cultural differences, political power dynamics, and economic interests.