While there were times of peace between the Indians and the Jamestown settlers, there were also many conflicts and wars. The most notable conflict was the Anglo-Powhatan Wars, which lasted from 1609 to 1646. The wars were fought over land, resources, and cultural differences. The Indians were often angry with the settlers because they felt that their land was being taken away from them and their way of life was being destroyed. The Jamestown settlers were also often afraid of the Indians and saw them as a threat to their survival.