- Caesar Rodney (1728-1784): Signer of the Declaration of Independence and prominent figure in Delaware's politics and government.
- George Read (1733-1789): Signer of the Declaration of Independence and influential politician who served as the first President of Delaware and a member of the Continental Congress.
- Thomas McKean (1734-1817): Signer of the Declaration of Independence and prominent lawyer and politician who served as the first Governor of Pennsylvania and as Chief Justice of the Supreme Court of Pennsylvania.
- John Dickinson (1732-1808): Statesman, lawyer, and political pamphleteer who served as a delegate to the Continental Congress and advocated for American rights against British authority.
- Nicholas Van Dyke (1738-1789): Lawyer, politician, and delegate to the Continental Congress who represented Delaware and helped draft the Articles of Confederation.
- David Hall (1714-1772): Printer, publisher, and postmaster who established one of the first printing presses in Delaware and printed influential newspapers such as the "Pennsylvania Gazette."
- Sarah Moore Grimke (1792-1873): Abolitionist, women's rights activist, and suffragist who was born and raised in Delaware before becoming a prominent figure in the abolitionist movement and women's rights movement in the United States.
- John M Clayton (1796-1856): Lawyer, politician, and Secretary of State under President Zachary Taylor who played a significant role in American politics and diplomacy during the mid-19th century.
- James A Baynard (1767-1815): Lawyer, politician, and member of the Continental Congress who served as a delegate representing Delaware and supported the ratification of the U.S. Constitution.