- Muhammad's teachings challenged the traditional religious beliefs and practices of the Quraysh. The Quraysh were fiercely devoted to their idols and the religion of their forefathers, and Muhammad's message of monotheism and the abandonment of idolatry was seen as a direct threat to their religious and cultural identity.
- Muhammad's success and growing popularity among the people of Mecca posed a political challenge to the Quraysh leadership. As more and more people embraced Islam, the influence and power of the Quraysh began to decline. This caused great concern and fear among the Quraysh leaders, who saw Muhammad as a potential rival and a threat to their authority and control over Mecca.
- Muhammad's criticism of the Quraysh's social and economic practices further added to their resentment and hostility. He condemned their wealth accumulation, exploitation of the poor, and the mistreatment of women. This challenged the prevailing social order and the privileges enjoyed by the Quraysh elite, which made them even more determined to silence Muhammad and suppress his teachings.
- The Quraysh were also motivated by personal grudges and animosities towards Muhammad. Some of the prominent Quraysh leaders, such as Abu Jahl, had personal conflicts with Muhammad and resented his growing influence and charisma. These personal rivalries and enmities further fueled their desire to eliminate Muhammad and put an end to his mission.
- The Quraysh feared the potential political and military consequences of Muhammad's movement. They were concerned that if Muhammad's teachings spread and gained widespread acceptance, it could lead to the decline of Mecca as a religious and commercial center. They also believed that Muhammad's call for social justice and the unity of the Arab tribes posed a threat to their political dominance and control over the Arabian Peninsula.
It is important to note that not all members of the Quraysh were hostile to Muhammad. Some, like Abu Bakr, embraced Islam and became his closest companions and supporters. However, the majority of the Quraysh leadership was opposed to him, and over time, their animosity and hostility grew, eventually leading to their attempts to assassinate him and ultimately, to his migration from Mecca to Medina in 622 CE.