- Harsh Weather Conditions: Champlain encountered harsh weather conditions during his explorations. The winters were extremely cold, with deep snow and frozen rivers. The summers were hot and humid, with frequent storms.
- Diseases: Champlain and his crew were often sick with various diseases, including dysentery, scurvy, and malaria. Many of his crew members died from these diseases, including Champlain's wife, Hélène.
- Native American Conflicts: Champlain had to contend with various Native American tribes during his time in North America. He was often involved in conflicts with the Iroquois, who resented the French presence in the region.
- Lack of Supplies: Champlain and his crew often faced shortages of food and other supplies. They had to rely on hunting and fishing to survive, and they sometimes had to go without essential items.
- Isolation: Champlain and his crew were often isolated from other European settlements. This made it difficult for them to receive help or supplies, and they were vulnerable to attack from hostile Native American tribes.
- Financial Difficulties: Champlain faced financial difficulties throughout his life. He was often in debt, and he struggled to raise money for his expeditions.
- Political Intrigue: Champlain was involved in political intrigue in both France and Canada. He had to navigate the complex political landscape, and he was sometimes the victim of political maneuvering by his rivals.