* 1307: The Knights Hospitaller, a Catholic military order, are expelled from the island of Rhodes by the Mamluks, a Muslim dynasty based in Egypt. The Knights Hospitaller would eventually move to the island of Malta, where they would remain until the 18th century.
* 1315-1317: The Great Famine strikes Europe, causing widespread starvation and death. The famine is estimated to have killed millions of people.
* 1321: Dante Alighieri, an Italian poet, completes his epic poem "The Divine Comedy." Considered to be one of the greatest works of literature in the Western world, "The Divine Comedy" tells the story of Dante's journey through Hell, Purgatory, and Heaven.
* 1337-1453: The Hundred Years' War, a conflict between England and France, begins. The war would last for over a century, and would see the rise of Joan of Arc, a French peasant girl who would lead the French army to several important victories.
* 1348: The Black Death, a devastating plague, reaches Europe. The plague would eventually kill an estimated 75-200 million people, making it one of the deadliest pandemics in history.