Conklin was a member of the prominent Conklin family of Long Island. He was the son of John Conklin and Abigail Tuthill. He was born in East Hampton, New York, and resided there for most of his life. He was a descendant of the original English settlers who founded East Hampton in the 17th century.
During his career as a privateer, Conklin commanded several ships and captured numerous prizes, including British merchant ships and French warships. He was known for his bravery and skill as a captain. He was also involved in the illicit trade of goods with foreign countries, which was common at the time among colonial merchants.
In addition to his privateering activities, Conklin was a successful entrepreneur and merchant. He owned several businesses, including a shipyard, a tavern, and a store. He was also a landowner and engaged in farming and animal husbandry. He played an important role in the economic development of East Hampton and the surrounding region.
Conklin was a respected and influential figure in the Province of New York. He was involved in local politics and served in various public offices, including as a justice of the peace and a member of the East Hampton Town Board. He was a respected member of the local community and contributed significantly to its growth and development.
Isaac Conklin died in 1755 at the age of approximately 75. He is remembered as a skilled sailor, entrepreneur, and public figure who played an important role in the colonial history of New York and the development of East Hampton.